Wellness Tips
Your guide for achieving optimal health ... |
How hormones, neurotransmitters and steroids work
Today I thought we would do a little biochemistry lesson to help you
understand how information is communicated within our bodies, and how that
information translates into cellular activity. It is the health of this
communication system that determines the health of the cells, and therefore the
systems, and therefore the organism which is you and me. When there is a
problem in the communication system and a cell does not get the message to stop
self-replicating for example, cancer occurs. Most of this
communication happens below our conscious awareness, although once we understand
the mechanism, it is possible for the conscious mind to have some influence on the system.
Our bodies are made up of various kinds of cells - blood cells, nerve cells,
muscle cells, bone cells, skin cells etc, and every cell on its surface, has
hundreds of thousands to millions of receptors, which are molecules made of
proteins that act a bit like keyholes, by providing access to the cell when the
proper key is inserted. Different kinds of receptors need different kinds
of keys. Depending on the kind of cell we are talking about, a cell may
have 50,000 receptors of one kind, and 10,000 of another kind, while a different
kind of cell may have a different proportion. Each cell has at least 70
different kinds of receptors on its surface, and more types of receptors may yet be discovered.
Candace Pert, a neuroscientist who did her PhD at Johns Hopkins, worked at the
National Institute for Health in Washington DC for 12 years, and was made famous by her discovery of the opiate
receptor in the early '70s, describes receptors as sensing or scanning molecules that wait to pick
up messages from the much smaller chemical "keys" that diffuse through the fluids that
surround the cells.
These chemical keys are called ligands, and they selectively bind to their
particular receptor on the cell surface. They come in three forms: neurotransmitters
such as histamine, serotonin, dopamine, norepinephrine, which tend to carry information from one nerve cell to the next.
The second ligand category are steroids, which include estrogen, progesterone,
testosterone and cortisol, and they are made from cholesterol. (See, we
NEED cholesterol!) The third and by far the largest category of ligand are
the peptides, made from amino acids (proteins), which form most of the hormones like insulin, glucagon,
melatonin, growth hormone, and prolactin for example. This huge category of
ligands is responsible for regulating almost all cell function and therefore
system function in the body.
So, how does it all work? Candace Pert describes it this way in her most interesting book
Molecules of Emotion "If the cell is the engine that drives all life, then the receptors are the buttons on the control panel of that engine, and a specific peptide (or other kind of ligand) is the finger that pushes the button and gets things started." The
ligand key fits into the keyhole of the receptor and delivers its message, and
the receptor then transmits the message to the interior of the cell, and the
cell carries out the action requested by the ligand. What the cell does
depends on what type of cell it is, and which type of receptor was bound. For example, and when insulin binds with the insulin receptor on a fat cell, sugar is turned into fat. When insulin binds on the insulin receptor on a liver cell, sugar is converted into glycogen. Along side the nervous system, this chemical communication system of receptor and ligand can be accurately viewed as a
basic network for communication, that connects every part of the body to every other
part of the body, similar in nature to the internet.
Because our cells are constantly replacing themselves to keep us new and young, can you understand how critical it is to this communication system that the raw material from which our cells, receptors and ligands
are made, is of the best quality possible? When we consume trans-fats, the body is tricked into thinking that we have eaten saturated fat, and it integrates the trans-fats into the cell membrane. But trans-fats are not saturated fats, (see, we NEED saturated fat!) and the
cell messaging critical to our health doesn't work. When we eat meats that are laden with antibiotics and hormones, those antibiotics and hormones interact with our receptors making our cells do things they shouldn't.
Many toxins in our environment create havoc in our cells by 1) either binding to our receptors,
like
the xeno-estrogens found in plastics that bind to our estrogen receptors, or 2)
becoming suspended in the cell membranes causing the receptors to change shape
resulting in sloppier messaging, like what happens when the heavy metals and
dioxins found in herbicides and pesticides enter our system when we breathe
them or when we consume them with our food.
Related Tips:Food, our raw material
How to avoid trans-fats
Fat - the misunderstood nutrient
Cholesterol does not cause heart disease
Plastic water bottles
Pert, Candace PhD, Molecules of Emotion Scribner, New York, NY, 1997.
www.wellnesstips.ca